Itchy leaf (Laportea decumana) is a native Papuan plant that has been used for generations by the Papuan people as an anti-pain medication. The use of this plant is very easy, residents just pick it and then apply it to the painful body part. This study aims to determine the physical quality of the gel preparation of itchy leaf extract (Laportea decumana) with variations in the bases of carbopol 940 (2.5%, 3.75%, 1.25%) and HPMC (2.5%, 1.25%). This type of research was an experimental laboratory research conducted in May 2022, located at the Pharmacy Laboratory of the Health Polytechnic of Jayapura the Ministry of Health. Samples were taken from Sentani Old Market, Jayapura Regency. The working procedure carried out was the preparation of simplicia and then extraction by maceration method to obtain a thick extract, then formulated with various variations of carbopol 940 (2.5%, 3.75%, 1.25%) and HPMC (2.5%, 1.25%). Each gel formulation was tested including organoleptic test, homogeneity test, PH test, dispersibility test, adhesion test and hedonic test. The results of the organoleptic test of the gel variation of carbopol 940 (2.5%, 3.75%, 1.25%) and HPMC (2.5%, 1.25%) met the requirements. The results of the homogeneity test of the three formulas did not meet the requirements. The results of the PH test on F I with variations in carbopol base 940 and HPMC 2.5% met the requirements while F II and F III did not meet the requirements. In the test of adhesion and dispersion, the results of the three painkiller gel formulas with variations of carbopol 940 (2.5%, 3.75%, 1.25%) and HPMC (2.5%, 1.25%) met the requirements. The hedonic test results showed that the panelists preferred formula II with a lower HPMC concentration than carbopol, which was 3.75%. From the results of the study, it can be concluded that F I meets the physical quality requirements except for homogeneity and for the hedonic test the panelists prefer F II for odor, shape and color.