African leaves (Vernonia amygdalina Del.) are very beneficial for health, including antibacterial, antiparasitic, antimalarial, antihelminthic, antiviral, anticancer, anticoagulant, analgesic and antipyretic, anti-inflammatory, antioxidant, liver protector and antidiabetic. This study aims to compare the physical quality of the anti-acne gel emulsion of African leaf extract (Vernonia amygdalina Del.) with carbopol gel base variations of 0.5%, 1%, 2% and viscolam 8%, 9%, 10%. The sample used in this study was African Leaf (Vernonia amygdalina Del.) obtained from the Jayapura area. This type of research is an experimental laboratory research conducted in June–July, at the Phytochemical Laboratory and Integrated Lab of the Health Polytechnic of the Ministry of Health Jayapura. Extracts from African leaves were tested for phytochemical screening which included saponin test, tannin test, and alkaloid test. The results of the organoleptic test on aroma and shape did not differ in the average gel base. While the average pH for all formulas is 5, and for the homogeneity test the six formulas are not homogeneous seen by macroscopic and microscopic means, and the dispersion that does not meet the requirements is only F2. Furthermore, for the adhesion test F1 and F3 showed results that did not meet the requirements with a value of less than 4 seconds. Then proceed with the emulsion type test where all formulas have an O/A type. From the results of the study, it can be concluded that F5 with 9% viscolam concentration met the requirements because the organoleptic test, pH, spreadability, adhesion and emulsion type had the best results.