Diarrhea is the main cause of death in children under five years old with 760,000 deaths each year. Although diarrhea in children does not cause death directly, it can be fatal if treated incorrectly. This study aims to determine the description of the use of antidiarrhea in pediatric patients at the Hamadi Community Health Center, Jayapura City with the parameters of age, gender, type of antidiarrheal drug and antibiotics, dosage of antidiarrheal drugs and antibiotics, appropriate dosage of antidiarrheal drugs and antibiotics, appropriate administration of antidiarrheal drugs and antibiotics, and appropriate duration of administration of antidiarrheal drugs and antibiotics. This research is a type of descriptive research with a retrospective data collection method using secondary data, namely based on prescription data from January to December 2022. This research was conducted in April 2023 on pediatric diarrhea patients at the Hamadi Health Center, Jayapura City with a population of 254 patients and a total sample of 155 patients.

The results of the study showed that drug use was based on the characteristics of diarrhea patients in children aged 1–5 years as many as 108 patients (70%), male gender as many as 82 patients (60%), type of zinc medication as many as 148 (69%), and cotrimoxazole as many as 117 (92%). The accuracy of zinc medication dosage was 148 (69%), and cotrimoxazole was 117 (92%). Incorrect dosage of ORS salt medication was 16 (7%), and cotrimoxazole was 14 (11%). Appropriate administration of zinc medication was 148 (69%), and cotrimoxazole was 103 (81%), inappropriate administration of ORS salt medication was 16 (7%), and cotrimoxazole was 14 (11%). The accuracy of the duration of administration of zinc medication was 148 (69%), and cotrimoxazole was 103 (81%), and the duration of administration of ORS salt medication was 16 (7%), and cotrimoxazole was 14 (11%).

Conclusion: the use of antidiarrheal in pediatric patients at the Hamadi Health Center mostly uses zinc and cotrimoxazole and the dosage is not correct and the duration of administration is not correct.